KLK6 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
Western blot of human salivary gland lysate with KLK6 polyclonal antibody (Cat # PAB15522).
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant KLK6.
Immunogen
Recombinant protein corresponding to full length human KLK6.
Host
Rabbit
Reactivity
Human
Specificity
Sequence has 85% identity with canine, 82% identity with horse and 80% identity with bovine. This antibody is useful for Western blot, where a band is seen ~38KDa due to glycosylation.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of human salivary gland lysate with KLK6 polyclonal antibody (Cat # PAB15522). -
Gene Info — KLK6
Entrez GeneID
5653Protein Accession#
Q92876Gene Name
KLK6
Gene Alias
Bssp, Klk7, MGC9355, NEUROSIN, PRSS18, PRSS9, SP59, ZYME, hK6
Gene Description
kallikrein-related peptidase 6
Omim ID
602652Gene Ontology
HyperlinkGene Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. The encoded enzyme is regulated by steroid hormones. In tissue culture, the enzyme has been found to generate amyloidogenic fragments from the amyloid precursor protein, suggesting a potential for involvement in Alzheimer's disease. Multiple alternatively spliced transcript variants that encode different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
kallikrein 6 (neurosin, zyme)|protease M|protease, serine, 18|protease, serine, 9
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Interactome
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Disease
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Publication Reference
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Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system.
Kuzmanov U, Jiang N, Smith CR, Soosaipillai A, Diamandis EP.
Molecular & Cellular Proteomics: MCP 2009 Apr; 8(4):791.
Application：ELISA, WB, Human, HEK 293 cells, ovarian cancer ascites fluids and CSFs from patients.
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Caveolin-1-mediated expression and secretion of kallikrein 6 in colon cancer cells.
Henkhaus RS, Roy UK, Cavallo-Medved D, Sloane BF, Gerner EW, Ignatenko NA.
Neoplasia 2008 Feb; 10(2):140.
Application：WB, Human, HCT-116 cels.
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Differential N-glycosylation of kallikrein 6 derived from ovarian cancer cells or the central nervous system.
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