Rabbit polyclonal antibody raised against synthetic peptide of LDLR.
A synthetic peptide corresponding to amino acids 500-550 of human LDLR.
Human, Mouse, Primates
This is specific to both the unglycosylated and glycosylated forms of the LDL Receptor. Immunogen has 100% homology with monkey and 92% homology with mouse. This antibody is useful for Western blot, where bands are seen ~95 KDa and ~160 KDa representing the unglycosylated and glycosylated forms of the LDL receptor, respectively.
Western Blot (0.5 ug/mL) The optimal working dilution should be determined by the end user.
In PBS (30% glycerol, 0.09% sodium azide)
Store at 4°C for short term. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. [provided by RefSeq
LDL receptor,low-density lipoprotein receptor class A domain-containing protein 3