SCD polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SCD.
Immunogen
A synthetic peptide corresponding to amino acids 50-100 of human SCD.
Host
Rabbit
Reactivity
Human
Specificity
This antibody is useful for Western blot analysis where a band can be seen at ~41 KDa.
Form
Liquid
Recommend Usage
Immunocytochemistry (1:50)
Immunofluorescence (1:50)
Western Blot (2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (30% glycerol, 0.09% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Tissue lysate)
Western blot of normal human liver lysate with SCD polyclonal antibody (Cat # PAB15510).Immunocytochemistry
Immunofluorescence
-
Gene Info — SCD
Entrez GeneID
6319Protein Accession#
O00767Gene Name
SCD
Gene Alias
FADS5, MSTP008, SCD1
Gene Description
stearoyl-CoA desaturase (delta-9-desaturase)
Omim ID
604031Gene Ontology
HyperlinkGene Summary
Stearoyl-CoA desaturase (SCD; EC 1.14.99.5) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5 (MIM 608370), have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Zhang et al. (1999) [PubMed 10229681]; Wang et al., 2005 [PubMed 15907797]).[supplied by OMIM
Other Designations
OTTHUMP00000020279|acyl-CoA desaturase|delta-9-desaturase|fatty acid desaturase|predicted protein of HQ0998|stearoyl-CoA desaturase
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver.
Mauvoisin D, Rocque G, Arfa O, Radenne A, Boissier P, Mounier C.
Journal of Cell Communication and Signaling 2007 Sep; 1(2):113.
Application:WB, Human, HepG2 cells.
-
Critical role of stearoyl-CoA desaturase-1 (SCD1) in the onset of diet-induced hepatic insulin resistance.
Gutierrez-Juarez R, Pocai A, Mulas C, Ono H, Bhanot S, Monia BP, Rossetti L.
The Journal of Clinical Investigation 2006 Jun; 116(6):1686.
Application:WB-Ti, Mouse, Mouse liver.
-
Role of the PI3-kinase/mTor pathway in the regulation of the stearoyl CoA desaturase (SCD1) gene expression by insulin in liver.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com