SLC40A1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC40A1.
Immunogen
A synthetic peptide corresponding to amino acids 250-300 of human SLC40A1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Western blot where a band is seen at ~62 KDa.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-glycine, 150 mM NaCl, pH 7.5 (0.05% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot of human intestine lysate with SLC40A1 polyclonal antibody (Cat # PAB15509). -
Gene Info — SLC40A1
Entrez GeneID
30061Protein Accession#
Q9NP59Gene Name
SLC40A1
Gene Alias
FPN1, HFE4, IREG1, MST079, MSTP079, MTP1, SLC11A3
Gene Description
solute carrier family 40 (iron-regulated transporter), member 1
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a cell membrane protein that may be involved in iron export from duodenal epithelial cells. Defects in this gene are a cause of hemochromatosis type 4 (HFE4). [provided by RefSeq
Other Designations
ferroportin 1|iron regulated gene 1|putative ferroportin 1 variant IIIB|solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3
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Interactome
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Disease
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Publication Reference
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N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells.
Rajitha Gadde, Swati Betharia.
Archives of Toxicology 2021 Aug; 95(8):2643.
Application:WB-Ce, Human, U-87 MG cells.
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Neuroprotective effects of disubstituted dithiolethione ACDT against manganese-induced toxicity in SH-SY5Y cells.
Neha Kulkarni, Rajitha Gadde, Kuljeet S Gugnani, Nguyen Vu, Claude Yoo, Rohan Zaveri, Swati Betharia.
Neurochemistry International 2021 Jul; 147:105052.
Application:WB-Ce, Human, SH-SY5Y cells.
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Upregulation of miR-18a-5p promotes the proliferation of prostate cancer via inhibiting the expression of SLC40A1.
Bin Liang, Cuixing Zhou, Shouxi Cui, Hao Lu, Renfang Xu, Dong Xue, Songnian Zou, Xiaozhou He.
Pathology, Research and Practice 2021 Aug; 224:153448.
Application:IHC, WB-Tr, Human, DU145 cells, Human prostate cancer, PC-3 cells.
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Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice.
Poli M, Anower-E-Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, Gordts PLSM, Arosio P, Esko JD.
The Journal of Biological Chemistry 2019 Sep; 294(36):13292.
Application:WB-Ti, Mouse, Mouse livers.
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Ferroportin-1 is a 'nuclear'-negative acute-phase protein in rat liver: a comparison with other iron-transport proteins.
Naz N, Malik IA, Sheikh N, Ahmad S, Khan S, Blaschke M, Schultze F, Ramadori G.
Laboratory Investigation 2012 Jun; 92(6):842.
Application:IF, WB-Ti, Rat, Liver, Spleen.
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Iron loading inhibits ferroportin1 expression in PC12 cells.
Chen Y, Qian ZM, Du J, Duan X, Chang Y, Wang Q, Wang C, Ma YM, Xu Y, Li L, Ke Y.
Neurochemistry International 2005 Dec; 47(7):507.
Application:WB, Rat, PC-12 cells.
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The iron exporter ferroportin/Slc40a1 is essential for iron homeostasis.
Donovan A, Lima CA, Pinkus JL, Pinkus GS, Zon LI, Robine S, Andrews NC.
Cell Metabolism 2005 Mar; 1(3):191.
Application:IHC-P, WB-Tr, Dog, Mouse, MDCK, Mouse embryos.
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N,N'bis-(2-mercaptoethyl) isophthalamide (NBMI) exerts neuroprotection against lead-induced toxicity in U-87 MG cells.
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