Rabbit polyclonal antibody raised against synthetic peptide of TLR9.
A synthetic peptide corresponding to amino acids 1019-1032 of human TLR9.
Human, Primates, Rat
Immunogen has 100% homology to monkey, 92% homology to rat, 86% homology to sheep, porcine and bovine and 85% homology to mouse. This antibody is useful for Western blot, where a band is seen ~120 KDa.
Western Blot (2 ug/mL) The optimal working dilution should be determined by the end user.
In Tris-citrate/phosphate, pH 7-8 (0.09% sodium azide)
Store at 4°C. Do not freeze.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This gene is preferentially expressed in immune cell rich tissues, such as spleen, lymph node, bone marrow and peripheral blood leukocytes. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq