TLR4 polyclonal antibody
* The price is valid only in USA. Please select country.
-
More Files
- More Functions
-
Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TLR4.
Immunogen
A synthetic peptide corresponding to amino acids 420-435 of human TLR4.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
Detects ~75-80KDa when tested against partial recombinant mouse TLR4 (extra-cellular portion plus His-tag).
Form
Liquid
Recommend Usage
Western Blot (1-3 ug/mL)
Immunohistochemistry (1:50)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% BSA, 0.09% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
Applications
Western Blot (Recombinant protein)
Western blot analysis of recombinant TLR4 protein with TLR4 polyclonal antibody (Cat # PAB15432).Immunohistochemistry
Immunochemical staining of mouse spleen tissue (A, B) and mouse colitis colon (C) with TLR4 polyclonal antibody (Cat # PAB15432).Immunocytochemistry
Flow Cytometry
-
Gene Info — TLR4
Entrez GeneID
7099Gene Name
TLR4
Gene Alias
ARMD10, CD284, TOLL, hToll
Gene Description
toll-like receptor 4
Omim ID
603030Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in placenta, and in myelomonocytic subpopulation of the leukocytes. It has been implicated in signal transduction events induced by lipopolysaccharide (LPS) found in most gram-negative bacteria. Mutations in this gene have been associated with differences in LPS responsiveness. Also, several transcript variants of this gene have been found, but the protein coding potential of most of them is uncertain. [provided by RefSeq
Other Designations
OTTHUMP00000022807|homolog of Drosophila toll
-
Interactome
-
Pathway
-
Disease
-
Publication Reference
-
Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients.
Go H, Koh J, Kim HS, Jeon KY, Chung DH.
Respiratory Medicine 2014 May; 108(5):783.
Application:IHC-P, Human, Lung.
-
Physical contact between lipopolysaccharide and toll-like receptor 4 revealed by genetic complementation.
Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B.
PNAS 2000 Feb; 97(5):2163.
-
Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.
Takeuchi O, Hoshino K, Kawai T, Sanjo H, Takada H, Ogawa T, Takeda K, Akira S.
Immunity 1999 Oct; 11(4):443.
-
The human toll signaling pathway: divergence of nuclear factor kappaB and JNK/SAPK activation upstream of tumor necrosis factor receptor-associated factor 6 (TRAF6).
Muzio M, Natoli G, Saccani S, Levrero M, Mantovani A.
The Journal of Experimental Medicine 1998 Jun; 187(12):2097.
-
Expression of toll-like receptor 2 and 4 is increased in the respiratory epithelial cells of chronic idiopathic interstitial pneumonia patients.
- +1-909-264-1399
+1-909-992-0619
Toll Free : +1-877-853-6098 - +1-909-992-3401
- sales@abnova.com