Ahsa1/Ahsa2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against Ahsa1/Ahsa2.
Immunogen
Mouse Ahsa1/Ahsa2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Detects ~ 38KDa.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
In antiserum
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of human cell lysates with Ahsa1/Ahsa2 polyclonal antibody (Cat # PAB15426).Immunohistochemistry
Immunocytochemistry
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
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Gene Info — Ahsa1
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Gene Info — Ahsa2
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Publication Reference
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Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
Holmes JL, Sharp SY, Hobbs S, Workman P.
Cancer Research 2008 Feb; 68(4):1188.
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A novel HSP90 chaperone complex regulates intracellular vesicle transport.
Lotz GP, Brychzy A, Heinz S, Obermann WM.
Journal of Cell Science 2008 Feb; 121(Pt 5):717.
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Aha1 competes with Hop, p50 and p23 for binding to the molecular chaperone Hsp90 and contributes to kinase and hormone receptor activation.
Harst A, Lin H, Obermann WM.
The Biochemical Journal 2005 May; 387(Pt 3):789.
Application:WB-Tr, Human, HEK 293 cells.
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Silencing of HSP90 cochaperone AHA1 expression decreases client protein activation and increases cellular sensitivity to the HSP90 inhibitor 17-allylamino-17-demethoxygeldanamycin.
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