HSPB8 polyclonal antibody
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More Files
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Immunofluorescence
Immunofluorescence staining of mouse spinal cord with HSPB8 polyclonal antibody (Cat # PAB15424).
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Specification
Product Description
Rabbit polyclonal antibody raised against HSPB8.
Immunogen
Human HSPB8.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Detects ~22KDa. Does not cross-react with Hsp27 or alpha-crystallin.
Form
Liquid
Purification
Peptide affinity purification
Recommend Usage
Immunofluorescence (1:100)
Immunohistochemistry (1:100)
Immunoprecipitation
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH7.4 (50% glycerol, 0.09% sodium azide).
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry
Immunofluorescence
Immunofluorescence staining of mouse spinal cord with HSPB8 polyclonal antibody (Cat # PAB15424).Immunoprecipitation
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Gene Info — HSPB8
Entrez GeneID
26353Gene Name
HSPB8
Gene Alias
CMT2L, DHMN2, E2IG1, H11, HMN2, HMN2A, HSP22
Gene Description
heat shock 22kDa protein 8
Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene belongs to the superfamily of small heat-shock proteins containing a conservative alpha-crystallin domain at the C-terminal part of the molecule. The expression of this gene in induced by estrogen in estrogen receptor-positive breast cancer cells, and this protein also functions as a chaperone in association with Bag3, a stimulator of macroautophagy. Thus, this gene appears to be involved in regulation of cell proliferation, apoptosis, and carcinogenesis, and mutations in this gene have been associated with different neuromuscular diseases, including Charcot-Marie-Tooth disease. [provided by RefSeq
Other Designations
E2-induced gene 1|heat shock 27kDa protein 8|heat shock protein beta-8|protein kinase H11|small stress protein-like protein HSP22
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Interactome
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Disease
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Publication Reference
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Correlation between the complex of small heat shock proteins (HSPBs) and the progression in patients with hepatocellular carcinoma.
Rie Matsushima-Nishiwaki, Hidenori Toyoda, Atsuyuki Maeda, Yuji Kaneoka, Takashi Kumada, Osamu Kozawa.
Archives of Biochemistry and Biophysics 2022 Dec; 732:109461.
Application：IP, Human, Huh-7 cells, Human hepatocellular carcinoma tumor.
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The problem of protein kinase activity of small heat shock protein Hsp22 (H11 or HspB8).
Kim MV, Seit-Nebi AS, Gusev NB.
Biochemical and Biophysical Research Communications 2004 Dec; 325(3):649.
Application：WB, Human, Mammalian cells.
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Interaction of human HSP22 (HSPB8) with other small heat shock proteins.
Sun X, Fontaine JM, Rest JS, Shelden EA, Welsh MJ, Benndorf R.
The Journal of Biological Chemistry 2004 Jan; 279(4):2394.
Application：WB-Ti, Monkey, Heart.
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HSP22, a new member of the small heat shock protein superfamily, interacts with mimic of phosphorylated HSP27 ((3D)HSP27).
Benndorf R, Sun X, Gilmont RR, Biederman KJ, Molloy MP, Goodmurphy CW, Cheng H, Andrews PC, Welsh MJ.
The Journal of Biological Chemistry 2001 Jul; 276(29):26753.
Application：WB-Tr, Monkey, COS-7 cells.
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Correlation between the complex of small heat shock proteins (HSPBs) and the progression in patients with hepatocellular carcinoma.
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