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Western Blot

Enzyme-linked Immunoabsorbent Assay

Immunodiffusion

Entrez GeneID

Gene Name

CFP

Gene Alias

BFD, PFC, PFD, PROPERDIN

Gene Description

complement factor properdin

Omim ID

Gene Ontology

Gene Summary

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified

Other Designations

properdin P factor, complement