Rabbit polyclonal antibody raised against full length recombinant RAD9A.
Recombinant protein corresponding to full length human RAD9A.
This antibody is useful for Western blot and immunohistochemistry. By Western blot a band is seen at approximately 42 KDa, however multiple bands may bee seen between ~40-60 KDa, depending on phosphorylation of the protein.
Immunohistochemistry (1:800) Western Blot (1:1000-1:1500) The optimal working dilution should be determined by the end user.
This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein is found to possess 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Use of alternative polyA sites has been noted for this gene. [provided by RefSeq
RAD9 homolog,cell cycle checkpoint control protein