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Last updated: 2016/11/27
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SREBF1 polyclonal antibody (DyLight 649)

  • Catalog # : PAB15198
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of SREBF1.
  • Immunogen:
  • A synthetic peptide corresponding to amino acids 700-800 of human SREBF1.
  • Host:
  • Rabbit
  • Reactivity:
  • Human, Mouse, Rat
  • Specificity:
  • 70% sequence identity with chicken protein. SREBP1 By Western blot a band is seen at ~65 KDa (mature form).
  • Form:
  • Liquid
  • Conjugation:
  • DyLight 649
  • Recommend Usage:
  • Western Blot (2 ug/ mL)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 50 mM sodium borate
  • Storage Instruction:
  • Store at 4°C. Do not freeze.
  • Applications
  • Western Blot
  • Application Image
  • Western Blot
  • Gene Information
  • Entrez GeneID:
  • 6720
  • Gene Name:
  • SREBF1
  • Gene Alias:
  • SREBP-1c,SREBP1,bHLHd1
  • Gene Description:
  • sterol regulatory element binding transcription factor 1
  • Gene Summary:
  • This gene encodes a transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a decamer flanking the low density lipoprotein receptor gene and some genes involved in sterol biosynthesis. The protein is synthesized as a precursor that is attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription by binding to the SRE1. Sterols inhibit the cleavage of the precursor, and the mature nuclear form is rapidly catabolized, thereby reducing transcription. The protein is a member of the basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor family. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
  • Other Designations:
  • sterol regulatory element binding protein-1
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