TRPA1 polyclonal antibody (DyLight 550)
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More Files
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of TRPA1.
Immunogen
A synthetic peptide corresponding to amino acids 1-100 of human TRPA1.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
69% sequence identity with mouse and rat proteins. TRPA1 This antibody can be used for Western blot analysis where a band is seen at ~110 KDa.
Form
Liquid
Conjugation
DyLight 550
Purification
Immunogen affinity purification
Recommend Usage
Immunohistochemistry (0.5-1 ug/mL)
Western Blot (2 ug/mL)
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:100-1:250)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM sodium borate (0.05% sodium azide).
Storage Instruction
Store at 4°C in the dark.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry
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Gene Info — TRPA1
Entrez GeneID
8989Protein Accession#
O75762Gene Name
TRPA1
Gene Alias
ANKTM1
Gene Description
transient receptor potential cation channel, subfamily A, member 1
Omim ID
604775Gene Ontology
HyperlinkGene Summary
The structure of the protein encoded by this gene is highly related to both the protein ankyrin and transmembrane proteins. The specific function of this protein has not yet been determined; however, studies indicate the function may involve a role in signal transduction and growth control. [provided by RefSeq
Other Designations
ankyrin-like protein 1|ankyrin-like with transmembrane domains 1
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Interactome
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Publication Reference
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Activation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs.
Katharina Müller-Dott, Sarah Christine Raßmuß, Marc-Michael Blum, Horst Thiermann, Harald John, Dirk Steinritz.
Toxicology Letters 2023 Mar; 376:51.
Application：WB-Ce, Human, HEK293 cells.
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Zinc chloride-induced TRPA1 activation does not contribute to toxicity in vitro.
Steinritz D, Zehfuß F, Stenger B, Schmidt A, Popp T, Kehe K, Mückter H, Thiermann H, Gudermann T.
Toxicology Letters 2018 Sep; 293:133.
Application：WB-Ce, Human, A-549, HEK 293 cells.
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Activation of the human TRPA1 channel by different alkylating sulfur and nitrogen mustards and structurally related chemotherapeutic drugs.
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