WNK4 polyclonal antibody (DyLight 488)
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of WNK4.
Immunogen
A synthetic peptide corresponding to amino acids 200-300 of human WNK4.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
This antibody can be used to detect mouse and human (very weakly) WNK4 protein. NB600-284 is specific to WNK4 protein. This antibody is useful for Western blot where a band is seen at ~135-155 kD. No other applications have been tested.
Form
Liquid
Conjugation
DyLight 488
Recommend Usage
Western Blot (2 ug/ mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM sodium borate
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Western Blot
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Gene Info — WNK4
Entrez GeneID
65266Gene Name
WNK4
Gene Alias
PHA2B, PRKWNK4
Gene Description
WNK lysine deficient protein kinase 4
Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB
Other Designations
protein kinase, lysine deficient 4
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Disease
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