AANAT polyclonal antibody (DyLight 488)
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Specification
Product Description
Rabbit polyclonal antibody raised against AANAT.
Immunogen
Human AANAT.
Host
Rabbit
Reactivity
Human, Primates
Specificity
Recognizes human and rhesus AANAT. It does not recognize rat, ovine, chicken or zebrafish AANAT. This is specific to primate AANAT (3,4). By Western blot, this antibody recognizes a band at 23 KDa representing hAANAT.
Form
Liquid
Conjugation
DyLight 488
Recommend Usage
Western Blot (1:500-1:1000)
Immunocytochemistry (1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM sodium borate
Storage Instruction
Store at 4°C. Do not freeze.
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Applications
Western Blot
Immunocytochemistry
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Gene Info — AANAT
Entrez GeneID
15Protein Accession#
U40347Gene Name
AANAT
Gene Alias
AA-NAT, SNAT
Gene Description
arylalkylamine N-acetyltransferase
Omim ID
600950Gene Ontology
HyperlinkGene Summary
Arylalkylamine N-acetyltransferase belongs to the superfamily of acetyltransferases. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for seasonal reproduction, modulates the function of the circadian clock in the suprachiasmatic nucleus, and influences activity and sleep. This enzyme is rapidly inactivated when animals are exposed to light at night. This protein is 80% identical to sheep and rat AA-NAT. Arylalkylamine N-acetyltransferase may contribute a multifactorial genetic diseases such as altered behavior in sleep/wake cycle. [provided by RefSeq
Other Designations
serotonin N-acetyltransferase
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Interactome
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Pathway
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Disease
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