Rabbit polyclonal antibody raised against native PLAU.
Native purified two chain human urinary type high molecular weight PLAU from pooled urine.
This antibody reacts only with human t-PA. No reactivity with human high molecular weight urokinase. Identity established by double diffusion with t-PA isolated from human, uterine tissue human and CHO derived recombinant t-PA. No other proteins so far tested showed greater than 1% cross reaction.
The optimal working dilution should be determined by the end user.
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
OTTHUMP00000019849,U-plasminogen activator,antagonist of uPA,plasminogen activator, urinary,urokinase plasminogen activator,urokinase-type plasminogen activator amino-terminal fragment