SERPINE1 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native SERPINE1.
Immunogen
Native purified human SERPINE1 from the HT 1080 fibrosarcoma cell line.
Host
Rabbit
Reactivity
Human
Specificity
This antibody reacts with human PAI-1s from endothelial cells. No reactivity with human PAI-2. Identity established by double diffusion with human PAI-1 isolated from human endothelial cells (HUVEC) culture and recombinant PAI-1 expressed in E.coli. No other proteins so far tested showed greater than 1% cross reaction.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In serum
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Immunohistochemistry (Frozen sections)
Immunocytochemistry
Immunofluorescence
Immunoprecipitation
Enzyme-linked Immunoabsorbent Assay
Radioimmunoassay
Inhibition Assay
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Gene Info — SERPINE1
Entrez GeneID
5054Gene Name
SERPINE1
Gene Alias
PAI, PAI-1, PAI1, PLANH1
Gene Description
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Omim ID
173360Gene Ontology
HyperlinkGene Summary
This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
plasminogen activator inhibitor, type I|plasminogen activator inhibitor-1|serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
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