Trpm2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of Trpm2.
Immunogen
A synthetic peptide corresponding to amino acids 1488-1506 at C-terminus of mouse Trpm2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Form
Liquid
Recommend Usage
ELISA (1 ug/mL)
Western Blot (1-5 ug/mL)
Immunohistochemistry (5-10 ug/mL)
Immunocytochemistry (1-5 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.1% proclin, 2% Block Ace)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunocytochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — Trpm2
Entrez GeneID
28240Gene Name
Trpm2
Gene Alias
9830168K16Rik, C79133, LTRPC2, TRPC7, Trp7, Trrp7
Gene Description
transient receptor potential cation channel, subfamily M, member 2
Gene Ontology
HyperlinkGene Summary
subfamily M
Other Designations
transient receptor potential channel 7|transient receptor protein 7
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Publication Reference
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TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
Yamamoto S, Shimizu S, Kiyonaka S, Takahashi N, Wajima T, Hara Y, Negoro T, Hiroi T, Kiuchi Y, Okada T, Kaneko S, Lange I, Fleig A, Penner R, Nishi M, Takeshima H, Mori Y.
Nature Medicine 2008 Jul; 14(7):738.
Application:IF, Mouse, monocytes.
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TRPM2 activation by cyclic ADP-ribose at body temperature is involved in insulin secretion.
Togashi K, Hara Y, Tominaga T, Higashi T, Konishi Y, Mori Y, Tominaga M.
The EMBO Journal 2006 May; 25(9):1804.
Application:IF, WB-Tr, Human, Rat, HEK 293, RIN-5F cells.
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LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death.
Hara Y, Wakamori M, Ishii M, Maeno E, Nishida M, Yoshida T, Yamada H, Shimizu S, Mori E, Kudoh J, Shimizu N, Kurose H, Okada Y, Imoto K, Mori Y.
Molecular Cell 2002 Jan; 9(1):163.
Application:IF, WB-Tr, Human, Rat, HEK 293, RIN-5F cells.
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TRPM2-mediated Ca2+influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration.
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