Lane 1 : Rat brain tissue lysate. Lane 2 : Rat small intestine tissue lysate. Lane 3 : Rat thymus lysate. Lane 4 : MCF-7 whole cell lysate. Lane 5 : HeLa whole cell lysate. Lane 6 : smmc whole cell lysate. Lane 7 : HT1080 whole cell lysate. Lane 8 : Colo320 whole cell lysate.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A