GRB2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of GRB2.
Immunogen
A synthetic peptide corresponding to amino acids 198-217 of human GRB2.
Host
Rabbit
Theoretical MW (kDa)
26
Reactivity
Human
Specificity
This antibody recognizes Grb2, a highly conserved approximately 26 KDa adaptorprotein.
Form
Liquid
Recommend Usage
Western Blot (1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% BSA, 0.09% sodium azide)
Storage Instruction
Store at 4°C. Do not freeze.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western Blotting analysis (reducing conditions) of Ramos cell lysate using GRB2 polyclonal antibody (Cat # PAB14689). -
Gene Info — GRB2
Entrez GeneID
2885Gene Name
GRB2
Gene Alias
ASH, EGFRBP-GRB2, Grb3-3, MST084, MSTP084
Gene Description
growth factor receptor-bound protein 2
Omim ID
108355Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene binds the epidermal growth factor receptor and contains one SH2 domain and two SH3 domains. Its two SH3 domains direct complex formation with proline-rich regions of other proteins, and its SH2 domain binds tyrosine phosphorylated sequences. This gene is similar to the Sem5 gene of C.elegans, which is involved in the signal transduction pathway. Two alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
HT027|OTTHUMP00000166096|OTTHUMP00000166097|OTTHUMP00000166098|abundant SRC homology|epidermal growth factor receptor-binding protein GRB2|growth factor receptor-bound protein 3
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Interactome
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Pathway
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Disease
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Publication Reference
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Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.
den Hertog J, Hunter T.
The EMBO Journal 1996 Jun; 15(12):3016.
Application:WB-Tr, WB-Ce, Human, Mouse, HEK 293, NIH/3T3 cells.
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GRB2 and phospholipase C-gamma 1 associate with a 36- to 38-kilodalton phosphotyrosine protein after T-cell receptor stimulation.
Sieh M, Batzer A, Schlessinger J, Weiss A.
Molecular and Cellular Biology 1994 Jul; 14(7):4435.
Application:IP, WB-Ce, Human, Jurkat cells.
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SH3 domains of the adapter molecule Grb2 complex with two proteins in T cells: the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated tyrosine kinases.
Reif K, Buday L, Downward J, Cantrell DA.
The Journal of Biological Chemistry 1994 May; 269(19):14081.
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Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains.
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