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Last updated: 2016/12/4
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PML polyclonal antibody

  • Catalog # : PAB14681
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against partial recombinant PML.
  • Immunogen:
  • Recombinant His fusion protein corresponding to B-BOX 1 region of human PML.
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • This antibody recognizes human PML.
  • Form:
  • Lyophilized
  • Recommend Usage:
  • Western Blot (1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • Lyophilized from 10 mM PBS, pH 7.2
  • Storage Instruction:
  • Store at -20°C on dry atmosphere.
    After reconstitution with deionized water, store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of extracts from NB4 cells using PML polyclonal antibody (Cat # PAB14681).
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5371
  • Gene Name:
  • PML
  • Gene Alias:
  • MYL,PP8675,RNF71,TRIM19
  • Gene Description:
  • promyelocytic leukemia
  • Gene Summary:
  • The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
  • Other Designations:
  • promyelocytic leukemia protein,promyelocytic leukemia, inducer of,tripartite motif protein TRIM19
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