PML polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot analysis of extracts from NB4 cells using PML polyclonal antibody (Cat # PAB14681).
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Specification
Product Description
Rabbit polyclonal antibody raised against partial recombinant PML.
Immunogen
Recombinant His fusion protein corresponding to B-BOX 1 region of human PML.
Host
Rabbit
Reactivity
Human
Specificity
This antibody recognizes human PML.
Form
Lyophilized
Recommend Usage
Western Blot (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from 10 mM PBS, pH 7.2
Storage Instruction
Store at -20°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Cell lysate)
Western blot analysis of extracts from NB4 cells using PML polyclonal antibody (Cat # PAB14681). -
Gene Info — PML
Entrez GeneID
5371Gene Name
PML
Gene Alias
MYL, PP8675, RNF71, TRIM19
Gene Description
promyelocytic leukemia
Omim ID
102578Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq
Other Designations
promyelocytic leukemia protein|promyelocytic leukemia, inducer of|tripartite motif protein TRIM19
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Interactome
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Pathway
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Disease
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