HAVCR2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of HAVCR2.
Immunogen
A synthetic peptide corresponding to amino acids 176-194 of human HAVCR2.
Sequence
ISTLANELRDSRLANDLRD
Host
Rabbit
Reactivity
Chimpanzee, Human
Specificity
The amino acid sequence used as immunogen is 100% homologous in human and 94% in chimp.
Form
Liquid
Recommend Usage
ELISA (1:100-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum (50% glycerol, 0.025% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Enzyme-linked Immunoabsorbent Assay
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Gene Info — HAVCR2
Entrez GeneID
84868Protein Accession#
NP_116171Gene Name
HAVCR2
Gene Alias
FLJ14428, KIM-3, TIM3, TIMD3, Tim-3
Gene Description
hepatitis A virus cellular receptor 2
Omim ID
606652Gene Ontology
HyperlinkGene Summary
CD4 (MIM 186940)-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells and their associated cytokines are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. The 2 types of cells also cross-regulate the functions of the other. TIM3 is a Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice.[supplied by OMIM
Other Designations
T cell immunoglobulin mucin 3|T cell immunoglobulin mucin-3|kidney injury molecule-3
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Interactome
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Disease
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Publication Reference
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Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
Sanchez-Fueyo A, Tian J, Picarella D, Domenig C, Zheng XX, Sabatos CA, Manlongat N, Bender O, Kamradt T, Kuchroo VK, Gutierrez-Ramos JC, Coyle AJ, Strom TB.
Nature Immunology 2003 Nov; 4(11):1093.
Application:Flow Cyt, IHC-P, Mouse, TH1 cells, Pancreatic islet.
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Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.
Monney L, Sabatos CA, Gaglia JL, Ryu A, Waldner H, Chernova T, Manning S, Greenfield EA, Coyle AJ, Sobel RA, Freeman GJ, Kuchroo VK.
Nature 2002 Jan; 415(6871):536.
Application:Flow Cyt, Func, Mouse, CHO cells, T cells.
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Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family.
McIntire JJ, Umetsu SE, Akbari O, Potter M, Kuchroo VK, Barsh GS, Freeman GJ, Umetsu DT, DeKruyff RH.
Nature Immunology 2001 Dec; 2(12):1109.
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Tim-3 inhibits T helper type 1-mediated auto- and alloimmune responses and promotes immunological tolerance.
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