RICTOR polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against RICTOR.
Immunogen
A portion of amino acids 1-50 of human RICTOR.
Host
Rabbit
Reactivity
Human, Mouse
Specificity
The amino acid sequence used is 100% homologous in human and 93% homologous in mouse. Increased concentration is recommended for western blot.
Form
Liquid
Recommend Usage
Western Blot (5-7 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of RICTOR in Jurkat cell lysate using RICTOR polyclonal antibody (Cat #PAB14568) at 7 &micrto;g/ml. -
Gene Info — RICTOR
Entrez GeneID
253260Protein Accession#
NP_689969Gene Name
RICTOR
Gene Alias
DKFZp686B11164, KIAA1999, MGC39830, mAVO3
Gene Description
rapamycin-insensitive companion of mTOR
Omim ID
609022Gene Ontology
HyperlinkGene Summary
RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM
Other Designations
TORC2-specific protein AVO3|pianissimo
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Interactome
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Pathway
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Disease
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Publication Reference
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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
Jacinto E, Loewith R, Schmidt A, Lin S, Ruegg MA, Hall A, Hall MN.
Nature Cell Biology 2004 Nov; 6(11):1122.
Application:IP-WB, WB-Tr, Human, HEK 293 cells.
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Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton.
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM.
Current Biology 2004 Jul; 14(14):1296.
Application:IP, WB, Human, DU145, HEK 293T, HeLa cells.
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Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive.
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