DAPK2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of DAPK2.
Immunogen
A mix of synthetic peptide corresponding to amino acids 325-342 and 347-364 of human DAPK2.
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
It will cross-react with mouse and rat DAPK2.
Form
Liquid
Recommend Usage
Western Blot (2-4 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.2% gelatin, 0.05% sodium azide)
Storage Instruction
Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
Western blot analysis of DAPK2 in rat kidney tissue lysate using DAPK2 polyclonal antibody (Cat #PAB14566) at 2 ug/mL . -
Gene Info — DAPK2
Entrez GeneID
23604Protein Accession#
NP_055141Gene Name
DAPK2
Gene Alias
DRP-1, MGC119312
Gene Description
death-associated protein kinase 2
Gene Ontology
HyperlinkGene Summary
This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. [provided by RefSeq
Other Designations
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Interactome
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Pathway
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Publication Reference
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DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A.
The Journal of Cell Biology 2002 Apr; 157(3):455.
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Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.
Shani G, Henis-Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, Admon A, Kimchi A.
The EMBO Journal 2001 Mar; 20(5):1099.
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Death-associated protein kinase-related protein 1, a novel serine/threonine kinase involved in apoptosis.
Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A.
Molecular and Cellular Biology 2000 Feb; 20(3):1044.
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DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death.
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