SLC31A1 polyclonal antibody
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More Files
- More Functions
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Panel A : Human SLC31A1 staining of human breast cancer tissue. Panel B : Human SLC31A1 antigen competition in human breast cancer tissue.
Immunocytochemistry
Staining of SLC31A1 overexpressing cell line with SLC31A1 polyclonal antibody (Cat # PAB14558). Panel B is antibody plus peptide competition staining.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SLC31A1.
Immunogen
A synthetic peptide corresponding to C-terminus of human SLC31A1.
Host
Rabbit
Reactivity
Human, Mouse, Pig, Rat, Xenopus, Zebra fish
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:250)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris-citrate/phosphate buffer, pH 7-8 (0.09% sodium azide)
Storage Instruction
Store at 4°C. Store at -20°C for long term. Avoid repeated freezing and thawing.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
Panel A : Human SLC31A1 staining of human breast cancer tissue. Panel B : Human SLC31A1 antigen competition in human breast cancer tissue.Immunocytochemistry
Staining of SLC31A1 overexpressing cell line with SLC31A1 polyclonal antibody (Cat # PAB14558). Panel B is antibody plus peptide competition staining. -
Gene Info — SLC31A1
Entrez GeneID
1317Protein Accession#
O15431Gene Name
SLC31A1
Gene Alias
COPT1, CTR1, MGC75487, hCTR1
Gene Description
solute carrier family 31 (copper transporters), member 1
Omim ID
603085Gene Ontology
HyperlinkGene Summary
Copper is an element essential for life, but excessive copper can be toxic or even lethal to the cell. Therefore, cells have developed sophisticated ways to maintain a critical copper balance, with the intake, export, and intracellular compartmentalization or buffering of copper strictly regulated. The 2 related genes ATP7A (MIM 300011) and ATP7B (MIM 606882), responsible for the human diseases Menkes syndrome (MIM 309400) and Wilson disease (MIM 277900), respectively, are involved in copper export. In S. cerevisiae, the copper uptake genes CTR1, CTR2, and CTR3 have been identified, and in human the CTR1 and CTR2 (MIM 603088) genes have been identified.[supplied by OMIM
Other Designations
OTTHUMP00000021950|copper transport 1 homolog|copper transporter 1
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Interactome
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Publication Reference
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Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation.
Zhang S, Liu H, Amarsingh GV, Cheung CC, Hogl S, Narayanan U, Zhang L, McHarg S, Xu J, Gong D, Kennedy J, Barry B, Choong YS, Phillips AR, Cooper GJ.
Cardiovascular Diabetology 2014 Jun; 13(1):100.
Application：IF, Rat, Left-ventricular.
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Enhanced delivery of cisplatin to intraperitoneal ovarian carcinomas mediated by the effects of bortezomib on the human copper transporter 1.
Jandial DD, Farshchi-Heydari S, Larson CA, Elliott GI, Wrasidlo WJ, Howell SB.
Clin Cancer Res 2009 Jan; 15(2):553.
Application：Flow cyt,IHC-P, Human, Treated 2008,Multiple tissue.
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PET of human prostate cancer xenografts in mice with increased uptake of 64CuCl2.
Peng F, Lu X, Janisse J, Muzik O, Shields AF.
Journal of Nuclear Medicine 2006 Oct; 47(10):1649.
Application：IHC, Human, Human prostate cancer.
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Expression of the human copper influx transporter 1 in normal and malignant human tissues.
Holzer AK, Varki NM, Le QT, Gibson MA, Naredi P, Howell SB.
The Journal of Histochemistry and Cytochemistry 2006 Sep; 54(9):1401.
Application：IHC-P, IF, Human, A2780 cells, Breast cancer, Stomach, Thyroid, Adrenal medulla, Pancreatic islet.
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Diabetic cardiomyopathy is associated with defective myocellular copper regulation and both defects are rectified by divalent copper chelation.
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