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Last updated: 2016/12/4
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PSEN1 polyclonal antibody

  • Catalog # : PAB14551
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of PSEN1.
  • Immunogen:
  • A synthetic peptide corresponding to N-terminus region and C-terminus region of human PSEN1.
  • Sequence:
  • MVELMFP, LLGLPID
  • Host:
  • Rabbit
  • Reactivity:
  • Human
  • Specificity:
  • Reacts with N terminal sequence MVELMFP and the C terminal sequence LLGLPID of the human PSDR1 protein.
  • Form:
  • Liquid
  • Recommend Usage:
  • The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In buffer containing 0.02% sodium azide
  • Storage Instruction:
  • Store at 4°C for short term. For long term storage store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Publication Reference
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of human PSEN1 in androgen-stimulated metastatic adenocarcinoma LNCaP FGC cells with PSEN1 polyclonal antibody (Cat # PAB14551) at 1 : 500 dilution.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Entrez GeneID:
  • 5663
  • Gene Name:
  • PSEN1
  • Gene Alias:
  • AD3,FAD,PS1,S182
  • Gene Description:
  • presenilin 1
  • Gene Summary:
  • Alzheimer's disease (AD) patients with an inherited form of the disease carry mutations in the presenilin proteins (PSEN1; PSEN2) or in the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of amyloid-beta (main component of amyloid deposits found in AD brains). Presenilins are postulated to regulate APP processing through their effects on gamma-secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma-secretase activity or themselves are protease enzymes. Several alternatively spliced transcript variants encoding different isoforms have been identified for this gene, the full-length nature of only some have been determined. [provided by RefSeq
  • Other Designations:
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