IKBKG polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against IKBKG.
Immunogen
N-terminus of human IKBKG.
Host
Rabbit
Reactivity
Human
Specificity
Reacts with the residues 2-13 [NRHLWKSQLCEM] of the IKK-g protein. Recognizes both human isoforms.
Form
Liquid
Recommend Usage
The optimal working dilution should be determined by the end user.
Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C for short term. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of IKBKG in interleukin-1-stimulated 293 cells with IKBKG polyclonal antibody (Cat # PAB14547) at a 1 : 500 dilution. -
Gene Info — IKBKG
Entrez GeneID
8517Gene Name
IKBKG
Gene Alias
AMCBX1, FIP-3, FIP3, Fip3p, IKK-gamma, IP, IP1, IP2, IPD2, NEMO
Gene Description
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma
Gene Ontology
HyperlinkGene Summary
This gene encodes the regulatory subunit of the inhibitor of kappaB kinase (IKK) complex, which activates NF-kappaB resulting in activation of genes involved in inflammation, immunity, cell survival, and other pathways. Mutations in this gene result in incontinentia pigmenti, hypohidrotic ectodermal dysplasia, and several other types of immunodeficiencies. Multiple transcript variants encoding different isoforms have been found for this gene. A pseudogene highly similar to this locus is located in an adjacent region of the X chromosome. [supplied by RefSeq
Other Designations
NFkappaB essential modulator|OTTHUMP00000026027|OTTHUMP00000026028|OTTHUMP00000026029|incontinentia pigmenti
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Interactome
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Pathway
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Disease
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Publication Reference
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Signal transduction. Docking IkappaB kinases.
Scheidereit C.
Nature 1998 Sep; 395(6699):225.
Application:WB-Ce, WB-Tr, Human, Mammalian cells.
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Signal transduction. Docking IkappaB kinases.
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