CHAT polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native CHAT.
Immunogen
Native purified CHAT from human placenta.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:1000)
Immunohistochemistry (1:100)
The optimal working dilution should be determined by the end user.Storage Buffer
In serum
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot (Tissue lysate)
Western blot of rat brain lysate showing specific immunolabeling of the ~68/70 kDa CHAT protein.Immunohistochemistry
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Gene Info — CHAT
Entrez GeneID
1103Gene Name
CHAT
Gene Alias
CMS1A, CMS1A2
Gene Description
choline acetyltransferase
Gene Ontology
HyperlinkGene Summary
This gene encodes an enzyme which catalyzes the biosynthesis of the neurotransmitter acetylcholine. This gene product is a characteristic feature of cholinergic neurons, and changes in these neurons may explain some of the symptoms of Alzheimer disease. Mutations in this gene are associated with congenital myasthenic syndrome associated with episodic apnea. Multiple transcript variants encoding different isoforms have been found for this gene, and some of these variants have been shown to encode more than one isoform. [provided by RefSeq
Other Designations
OTTHUMP00000019583|OTTHUMP00000019584|acetyl CoA:choline O-acetyltransferase
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Interactome
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Pathway
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Disease
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Publication Reference
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Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas.
Sinclair LI, Kumar A, Darreh-Shori T, Love S.
Alzheimer's Research & Therapy 2019 Sep; 11(1):80.
Application:ELISA, Human, Brain extracted.
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Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease Brain.
Darreh-Shori T, Rezaeianyazdi S, Lana E, Mitra S, Gellerbring A, Karami A, Bogdanovic N, Lithner CU, Winblad B, Behbahani H.
Molecular Neurobiology 2018 Oct; [Epub].
Application:ELISA, Human, Human brains.
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Fibrillar β-amyloid 1-42 alters cytokine secretion, cholinergic signalling and neuronal differentiation.
Malmsten L, Vijayaraghavan S, Hovatta O, Marutle A, Darreh-Shori T.
Journal of Cellular and Molecular Medicine 2014 Sep; 18(9):1874.
Application:ELISA, Human, Neurosphere.
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Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway.
Vijayaraghavan S, Karami A, Aeinehband S, Behbahani H, Grandien A, Nilsson B, Ekdahl KN, Lindblom RP, Piehl F, Darreh-Shori T.
PLoS One 2013 Jun; 8(6):e65936.
Application:Dot, WB, WB-Ti, Human, CSF, Plasma.
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Visual hallucinations in Alzheimer's disease do not seem to be associated with chronic hypoperfusion of to visual processing areas V2 and V3 but may be associated with reduced cholinergic input to these areas.
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