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Immunohistochemistry

Immunocytochemistry

Entrez GeneID

Gene Name

IGLL1

Gene Alias

14.1, CD179b, IGL1, IGL5, IGLJ14.1, IGLL, IGO, IGVPB, VPREB2

Gene Description

immunoglobulin lambda-like polypeptide 1

Omim ID

Gene Ontology

Gene Summary

The preB cell receptor is found on the surface of proB and preB cells, where it is involved in transduction of signals for cellular proliferation, differentiation from the proB cell to the preB cell stage, allelic exclusion at the Ig heavy chain gene locus, and promotion of Ig light chain gene rearrangements. The preB cell receptor is composed of a membrane-bound Ig mu heavy chain in association with a heterodimeric surrogate light chain. This gene encodes one of the surrogate light chain subunits and is a member of the immunoglobulin gene superfamily. This gene does not undergo rearrangement. Mutations in this gene can result in B cell deficiency and agammaglobulinemia, an autosomal recessive disease in which few or no gamma globulins or antibodies are made. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq

Other Designations

CD179b antigen|Pre-B lymphocyte-specific protein-2|immunoglobulin omega polypeptide chain|immunoglobulin-related 14.1 protein|lambda5