AFP polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against AFP.
Immunogen
Human AFP.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) (1:50-1:200)
Immunohistochemistry (Frozen sections) (1:50-1:200)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.4 (1% BSA, 0.05% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Immunohistochemistry
Immunocytochemistry
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Gene Info — AFP
Entrez GeneID
174Gene Name
AFP
Gene Alias
FETA, HPAFP
Gene Description
alpha-fetoprotein
Omim ID
104150Gene Ontology
HyperlinkGene Summary
This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatoma or teratoma. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq
Other Designations
OTTHUMP00000160480|alpha-1-fetoprotein|alpha-fetoglobulin
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Interactome
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Disease
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Publication Reference
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Yolk sac tumor of the liver combined with hepatocellular carcinoma.
Morinaga S, Nishiya H, Inafuku T.
Arch Pathol Lab Med 1996 Jul; 120(7):687.
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Biological role of alpha-fetoprotein in the endocrinological field: data and hypotheses.
Nunez EA.
Tumour Biology 1994 Jan; 15(2):63.
Application：ELISA, WB, Human, Mouse, Digestive tract, Embryonic yolk, Livers, Lymphocytes, Nervous system, Plasma, Uterus.
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Alpha-fetoprotein localization in pure ovarian teratoma. An immunohistochemical study of 12 cases.
Perrone T, Steeper TA, Dehner LP.
American Journal of Clinical Pathology 1987 Dec; 88(6):713.
Application：IHC-P, Human, Human ovarian teratoma.
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Yolk sac tumor of the liver combined with hepatocellular carcinoma.
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