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Last updated: 2016/10/16
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SIRPA polyclonal antibody

  • Catalog # : PAB14459
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  • Specification
  • Product Description:
  • Rabbit polyclonal antibody raised against synthetic peptide of SIRPA.
  • Immunogen:
  • A synthetic peptide corresponding to C-terminus of human SIRPA.
  • Host:
  • Rabbit
  • Reactivity:
  • Bovine, Human, Mouse, Rat
  • Form:
  • Liquid
  • Recommend Usage:
  • Western Blot (1:1000-1:2000)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In PBS, pH 7.4 (0.02% sodium azide)
  • Storage Instruction:
  • Store at -20°C.
    Aliquot to avoid repeated freezing and thawing.
  • Note:
  • This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
  • Applications
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • Western blot analysis of SIRP alpha in THP-1 cell lysate with SIRPA polyclonal antibody (Cat # PAB14459) at 1:2000 dilution. Bands of molecular weight 75-110 kDa correspond to SIRP alpha 1, 2 and 3.
  • Application Image
  • Western Blot (Cell lysate)
  • Western Blot (Cell lysate)
  • enlarge
  • Gene Information
  • Gene Name:
  • Gene Alias:
  • Gene Description:
  • signal-regulatory protein alpha
  • Gene Summary:
  • The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein can be phosphorylated by tyrosine kinases. The phospho-tyrosine residues of this PTP have been shown to recruit SH2 domain containing tyrosine phosphatases (PTP), and serve as substrates of PTPs. This protein was found to participate in signal transduction mediated by various growth factor receptors. CD47 has been demonstrated to be a ligand for this receptor protein. This gene and its product share very high similarity with several other members of the SIRP family. These related genes are located in close proximity to each other on chromosome 20p13. Multiple alternatively spliced transcript variants have been determined for this gene. [provided by RefSeq
  • Other Designations:
  • OTTHUMP00000030001,SHP substrate-1,brain-immunoglobulin-like molecule with tyrosine-based activation motifs,macrophage fusion receptor,myd-1 antigen,protein tyrosine phosphatase, non-receptor type substrate 1,signal regulatory protein, alpha type 1,signal
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