PSMB10 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
PSMB10 polyclonal antibody (Cat # PAB14399) (0.3 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of PSMB10.
Immunogen
A synthetic peptide corresponding to human PSMB10.
Sequence
C-PTEPVKRSGRYH
Host
Goat
Theoretical MW (kDa)
28.9
Reactivity
Human
Specificity
Approx 26 KDa band observed in human, liver, lung and lymph node lysates (calculated MW of 28.9 KDa according to NP_002792.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:8000)
Western Blot (0.3-1 ug/mL).)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
PSMB10 polyclonal antibody (Cat # PAB14399) (0.3 ug/mL) staining of human lung lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — PSMB10
Entrez GeneID
5699Protein Accession#
NP_002792.1Gene Name
PSMB10
Gene Alias
LMP10, MECL1, MGC1665, beta2i
Gene Description
proteasome (prosome, macropain) subunit, beta type, 10
Omim ID
176847Gene Ontology
HyperlinkGene Summary
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Proteolytic processing is required to generate a mature subunit. Expression of this gene is induced by gamma interferon, and this gene product replaces catalytic subunit 2 (proteasome beta 7 subunit) in the immunoproteasome. [provided by RefSeq
Other Designations
macropain subunit MECl-1|multicatalytic endopeptidase complex subunit MECl-1|proteasome MECl-1|proteasome beta 10 subunit|proteasome catalytic subunit 2i|proteasome subunit MECL1|proteasome subunit beta 7i
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Interactome
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Pathway
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Disease
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Publication Reference
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CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.
Moschonas A, Kouraki M, Knox PG, Thymiakou E, Kardassis D, Eliopoulos AG.
Molecular and Cellular Biology 2008 Oct; 28(20):6208.
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CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1.
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