XPNPEP1 polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of XPNPEP1.
Immunogen
A synthetic peptide corresponding to human XPNPEP1.
Sequence
C-LIRETQPISKQH
Host
Goat
Theoretical MW (kDa)
69.9
Reactivity
Human
Specificity
Approx 80 KDa band observed in human heart, skeletal muscle and pancreas lysates (calculated MW of 69.9 KDa according to NP_065116.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
XPNPEP1 polyclonal antibody (Cat # PAB14395) (0.3 ug/mL) staining of human pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — XPNPEP1
Entrez GeneID
7511Protein Accession#
NP_065116.2Gene Name
XPNPEP1
Gene Alias
SAMP, XPNPEP, XPNPEPL, XPNPEPL1
Gene Description
X-prolyl aminopeptidase (aminopeptidase P) 1, soluble
Omim ID
602443Gene Ontology
HyperlinkGene Summary
X-prolyl aminopeptidase (EC 3.4.11.9) is a proline-specific metalloaminopeptidase that specifically catalyzes the removal of any unsubstituted N-terminal amino acid that is adjacent to a penultimate proline residue. Because of its specificity toward proline, it has been suggested that X-prolyl aminopeptidase is important in the maturation and degradation of peptide hormones, neuropeptides, and tachykinins, as well as in the digestion of otherwise resistant dietary protein fragments, thereby complementing the pancreatic peptidases. Deficiency of X-prolyl aminopeptidase results in excretion of large amounts of imino-oligopeptides in urine (Blau et al., 1988 [PubMed 3141711]).[supplied by OMIM
Other Designations
OTTHUMP00000020457|OTTHUMP00000058856|X-prolyl aminopeptidase (aminopeptidase P) 1, soluble (SAMP, XPNPEP, XPNPEPL)|X-prolyl aminopeptidase (aminopeptidase P)-like
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Interactome
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Disease
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Publication Reference
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Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J.
Nature Biotechnology 2003 May; 21(5):566.
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Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.
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