Goat polyclonal antibody raised against native COL3A1.
Native human COL3A1.
Reacts with conformational determinants on human type III collagen as demonstrated by ELISA. May react with type III collagen from other species. Exhibits <10% cross reactivity with collagen type I, II, IV, V, VI. This antibody has not been tested for reactivity with other ECM proteins (e.g., laminin, fibronectin).
Immunocytochemistry (1:10-1:20) Immunohistochemistry (1:10-1:20) The optimal working dilution should be determined by the end user.
This gene encodes the pro-alpha1 chains of type III collagen, a fibrillar collagen that is found in extensible connective tissues such as skin, lung, uterus, intestine and the vascular system, frequently in association with type I collagen. Mutations in this gene are associated with Ehlers-Danlos syndrome types IV, and with aortic and arterial aneurysms. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
Ehlers-Danlos syndrome type IV, autosomal dominant,alpha1 (III) collagen,collagen type III alpha 1,collagen, fetal