LRRK2 polyclonal antibody
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Specification
Product Description
Sheep polyclonal antibody raised against synthetic peptide of LRRK2.
Immunogen
A synthetic peptide (conjugated with blue carrier protein) corresponding to amino acids 946-962 of human LRRK2.
Sequence
LKRKRKILSSDDSLRSS
Host
Sheep
Reactivity
Human
Specificity
Specificity for LRRK2 has been confirmed by IHC.
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:500-1:10000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
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Gene Info — LRRK2
Entrez GeneID
120892Gene Name
LRRK2
Gene Alias
AURA17, DARDARIN, PARK8, RIPK7, ROCO2
Gene Description
leucine-rich repeat kinase 2
Gene Ontology
HyperlinkGene Summary
This gene is a member of the leucine-rich repeat kinase family and encodes a protein with an ankryin repeat region, a leucine-rich repeat (LRR) domain, a kinase domain, a DFG-like motif, a RAS domain, a GTPase domain, a MLK-like domain, and a WD40 domain. The protein is present largely in the cytoplasm but also associates with the mitochondrial outer membrane. Mutations in this gene have been associated with Parkinson disease-8. [provided by RefSeq
Other Designations
Parkinson disease (autosomal dominant) 8|augmented in rheumatoid arthritis 17
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Interactome
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Disease
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Publication Reference
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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T.
Neuron 2004 Nov; 44(4):601.
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Complete sequencing and characterization of 21,243 full-length human cDNAs.
Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K
Nature Genetics 2003 Dec; 36(1):40.
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Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
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