Intense NTN-like immunostaining localized to the intestinal crypt and villus epithelium and muscle layers, cryo-sections of tissues fixed by Zamboni's fixative. Immunohistochemical detection of NRTN using NRTN polyclonal antibody (Cat # PAB14338) at a 1 : 2000 dilution.
Neurturin is a member of the TGF-beta subfamily, TRN. This gene signals through RET and a GPI-linked coreceptor, and promotes survival of neuronal populations. A neurturin mutation has been described in a family with Hirschsprung Disease. [provided by RefSeq