Immunohistochemistry using DAB substrate showing intense staining in the rat airway epithelium using AP1G1 polyclonal antibody (Cat # PAB14334) at a dilution of 1 : 500. Secondary antibody was biotinylated goat and rabbit at a dilution of 1 : 3000 followed by Vector ABC. This antigen has a similar distribution to clathrin, with which it associates.
Adaptins are important components of clathrin-coated vesicles transporting ligand-receptor complexes from the plasma membrane or from the trans-Golgi network to lysosomes. The adaptin family of proteins is composed of four classes of molecules named alpha, beta-, beta prime- and gamma- adaptins. Adaptins, together with medium and small subunits, form a heterotetrameric complex called an adaptor, whose role is to promote the formation of clathrin-coated pits and vesicles. The protein encoded by this gene is a gamma-adaptin protein and it belongs to the adaptor complexes large subunits family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
clathrin assembly protein complex 1 gamma large chain,clathrin-associated/assembly/adaptor protein, large, gamma 1,gamma adaptin,golgi adaptor HA1/AP1 adaptin gamma subunit