Rabbit polyclonal antibody raised against partial NTRK1.
Glycosylated human extracellular domain NTRK1.
Human, Mouse, Rat
Specificity was demonstrated by immunohistochemistry. When used for immunohistochemistry in rat dorsal root ganglia, staining is restricted to the known distribution of TrkA, that is in small, nociceptive neurons.
ELISA (1:5000) Immunohistochemistry (1:1000) The optimal working dilution should be determined by the end user.
Lyophilized from PBS
Store at 4°C on dry atmosphere. After reconstitution with deionized water, store at -20°C or lower. Aliquot to avoid repeated freezing and thawing.
Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat trigeminal nerve (free floating cryostat section) using NTRK1 polyclonal antibody (Cat # PAB14332) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.
Immunohistochemistry (Frozen sections)
Immunohistochemical staining of Tyrosine Kinase Receptor A (TrkA) in rat spinal cord (free floating cryostat section) using NTRK1 polyclonal antibody (Cat # PAB14332) at a dilution of 1 in 2000. Courtesy of Professor Xin Fu Zhou, The Flinders University of South Australia.
This gene encodes a member of the neurotrophic tyrosine kinase receptor (NTKR) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. The presence of this kinase leads to cell differentiation and may play a role in specifying sensory neuron subtypes. Mutations in this gene have been associated with congenital insensitivity to pain, anhidrosis, self-mutilating behavior, mental retardation and cancer. Alternate transcriptional splice variants of this gene have been found, but only three have been characterized to date. [provided by RefSeq
OTTHUMP00000038736,Oncogene TRK,high affinity nerve growth factor receptor,tyrosine kinase receptor A