SNCA polyclonal antibody
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More Files
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Immunohistochemistry
Immunohistochemical staining detection of cortical Lewy Bodies (inclusions) and Lewy neurites from a patient with Dementia Lewy Bodies. Primary antibody was SNCA polyclonal antibody (Cat # PAB14318) at a dilution of 1 : 1000, visualised with Avidin-Biotin-Peroxidase and DAB.
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of SNCA.
Immunogen
A synthetic peptide (conjugated with blue carrier protein) corresponding to amino acids 129-140 of human SNCA.
Sequence
SEEGYQDYEPEA
Host
Rabbit
Reactivity
Human, Mouse, Rat
Specificity
Immunohistochemical and western blot analysis of human brain indicates a high level of specificity for this antiserum.
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:500-1:3000)
Western Blot (1:500-1:3000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Immunohistochemical staining detection of cortical Lewy Bodies (inclusions) and Lewy neurites from a patient with Dementia Lewy Bodies. Primary antibody was SNCA polyclonal antibody (Cat # PAB14318) at a dilution of 1 : 1000, visualised with Avidin-Biotin-Peroxidase and DAB. -
Gene Info — SNCA
Entrez GeneID
6622Gene Name
SNCA
Gene Alias
MGC110988, NACP, PARK1, PARK4, PD1
Gene Description
synuclein, alpha (non A4 component of amyloid precursor)
Gene Ontology
HyperlinkGene Summary
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000161559|OTTHUMP00000161561|alpha synuclein|alpha-synuclein|alpha-synuclein, isoform NACP140|non A-beta component of AD amyloid|non A4 component of amyloid
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Interactome
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Disease
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Publication Reference
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Pathogenic effects of alpha-synuclein aggregation.
Lundvig D, Lindersson E, Jensen PH.
Brain Research. Molecular Brain Research 2005 Mar; 134(1):3.
Application：WB, Human, Human mammalian cells.
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The role of alpha-synuclein in neurodegenerative diseases.
Bennett MC.
Pharmacology & Therapeutics 2005 Mar; 105(3):311.
Application：IF, IHC, WB, Human, HEK 293 cells, Human brains.
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Neurobiology of alpha-synuclein.
Vekrellis K, Rideout HJ, Stefanis L.
Molecular Neurobiology 2004 Aug; 30(1):1.
Application：IHC, WB, Human, Rat, HEK 293, Human brains, PC-12 cells.
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Pathogenic effects of alpha-synuclein aggregation.
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