OXT polyclonal antibody
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More Files
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Immunohistochemistry (Frozen sections)
The cryostat section of the sheep hypothalamus was incubated in OXT polyclonal antibody (Cat # PAB14310) at the dilution of 1 : 1000 overnight followed by incubation with biotinylated secondary antibodies. Cell bodies and nerve terminals (from cells that produce this hormone) in the sheep brain are intensely stained. This figure shows staining of cells when no pre-absorption is performed.
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Specification
Product Description
Guinea pig polyclonal antibody raised against synthetic peptide of OXT.
Immunogen
A synthetic peptide (conjugated with carrier protein) corresponding to amino acids 20-28 of human OXT.
Sequence
YIQNCPLG
Host
Guinea pig
Reactivity
Human, Sheep
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry (Frozen sections)
The cryostat section of the sheep hypothalamus was incubated in OXT polyclonal antibody (Cat # PAB14310) at the dilution of 1 : 1000 overnight followed by incubation with biotinylated secondary antibodies. Cell bodies and nerve terminals (from cells that produce this hormone) in the sheep brain are intensely stained. This figure shows staining of cells when no pre-absorption is performed. -
Gene Info — OXT
Entrez GeneID
5020Protein Accession#
P01178;P13389;P01175;P35454;P01179Gene Name
OXT
Gene Alias
MGC126890, MGC126892, OT, OT-NPI
Gene Description
oxytocin, prepropeptide
Omim ID
167050Gene Ontology
HyperlinkGene Summary
There are two proteins encoded by this gene, oxytocin and neurophysin I. Oxytocin is posterior pituitary hormone which is synthesized as an inactive precursor in the hypothalamus along with its carrier protein neurophysin I. Together with neurophysin, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream. The precursor seems to be activated while it is being transported along the axon to the posterior pituitary. This hormone contracts smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. [provided by RefSeq
Other Designations
OTTHUMP00000030079|neurophysin I|oxytocin, prepro- (neurophysin I)|oxytocin-neurophysin I|oxytocin-neurophysin I, preproprotein
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Interactome
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Pathway
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Disease
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Publication Reference
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Oxytocin induces penile erection and yawning when injected into the bed nucleus of the stria terminalis: a microdialysis and immunohistochemical study.
Bratzu J, Bharatiya R, Manca E, Cocco C, Argiolas A, Melis MR, Sanna F.
Behavioural Brain Research 2019 Dec; 375:112147.
Application：IHC, Rat, Brain.
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A role for oxytocin and 5-HT(1A) receptors in the prosocial effects of 3,4 methylenedioxymethamphetamine ("ecstasy").
Thompson MR, Callaghan PD, Hunt GE, Cornish JL, McGregor IS.
Neuroscience 2007 May; 146(2):509.
Application：IHC, Rat, Rat brain.
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Oxytocin induces penile erection and yawning when injected into the bed nucleus of the stria terminalis: a microdialysis and immunohistochemical study.
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