POMC (gamma) polyclonal antibody
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Specification
Product Description
Guinea pig polyclonal antibody raised against synthetic peptide of POMC (gamma).
Immunogen
A synthetic peptide (conjugated with carrier protein) corresponding to amino acids 77-88 of human POMC (gamma).
Sequence
YVMGHFRWDRFG
Host
Guinea pig
Reactivity
Human, Sheep
Form
Lyophilized
Recommend Usage
Immunohistochemistry (1:2000)
The optimal working dilution should be determined by the end user.Storage Buffer
Lyophilized from PBS
Storage Instruction
Store at 4°C on dry atmosphere.
After reconstitution with deionized water, store at -20°C or lower.
Aliquot to avoid repeated freezing and thawing. -
Applications
Immunohistochemistry
Immunofluorescence
The cryostat section of the sheep hypothalamus was incubated in POMC (gamma) polyclonal antibody (Cat # PAB14307) at the dilution of 1 : 1000 overnight followed by incubation with FITC- conjugated secondary antibodies. Cell bodies and nerve terminals in the sheep brain are intensely stained. -
Gene Info — POMC
Entrez GeneID
5443Protein Accession#
P01189Gene Name
POMC
Gene Alias
ACTH, CLIP, LPH, MSH, NPP, POC
Gene Description
proopiomelanocortin
Gene Ontology
HyperlinkGene Summary
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq
Other Designations
OTTHUMP00000119991|adrenocorticotropic hormone|adrenocorticotropin|alpha-MSH|alpha-melanocyte-stimulating hormone|beta-LPH|beta-MSH|beta-endorphin|beta-melanocyte-stimulating hormone|corticotropin-like intermediary peptide|gamma-LPH|gamma-MSH|lipotropin b
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Publication Reference
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Prenatal development of hypothalamic neuropeptide systems in the nonhuman primate.
Grayson BE, Allen SE, Billes SK, Williams SM, Smith MS, Grove KL.
Neuroscience 2006 Dec; 143(4):975.
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Prenatal development of hypothalamic neuropeptide systems in the nonhuman primate.
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