MAP3K11 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against recombinant MAP3K11.
Immunogen
Recombinant protein corresponding to human MAP3K11.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:500-1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS, pH 7.2 (50% glycerol, 0.01% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Recombinant protein)
Western blot analysis using MAP3K11 polyclonal antibody (Cat # PAB14284) against recombinant human MAP3K11 expressed in E. coli.Enzyme-linked Immunoabsorbent Assay
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Gene Info — MAP3K11
Entrez GeneID
4296Gene Name
MAP3K11
Gene Alias
MGC17114, MLK-3, MLK3, PTK1, SPRK
Gene Description
mitogen-activated protein kinase kinase kinase 11
Omim ID
600050Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq
Other Designations
SH3 domain-containing proline-rich kinase|mixed lineage kinase 3|protein-tyrosine kinase PTK1
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Interactome
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Pathway
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Publication Reference
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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.
Rana A, Gallo K, Godowski P, Hirai S, Ohno S, Zon L, Kyriakis JM, Avruch J.
The Journal of Biological Chemistry 1996 Aug; 271(32):19025.
Application:IP, WB-Tr, Monkey, COS cells.
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The mixed lineage kinase SPRK phosphorylates and activates the stress-activated protein kinase activator, SEK-1.
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