GJA1 polyclonal antibody
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More Files
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Western Blot (Tissue lysate)
GJA1 polyclonal antibody (Cat # PAB14139) (0.3 ug/mL) staining of rat brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of GJA1.
Immunogen
A synthetic peptide corresponding to human GJA1.
Sequence
C-QPFDFPDDNQNSKK
Host
Goat
Theoretical MW (kDa)
43
Reactivity
Rat
Specificity
Approx 40 KDa band observed in rat brain lysates (calculated MW of 43.0 KDa according to human NP_000156.1 and to Rat NP_036699.1).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:64000)
Western Blot (0.3-1 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Tissue lysate)
GJA1 polyclonal antibody (Cat # PAB14139) (0.3 ug/mL) staining of rat brain lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — GJA1
Entrez GeneID
2697Protein Accession#
NP_000156.1Gene Name
GJA1
Gene Alias
CX43, DFNB38, GJAL, ODDD
Gene Description
gap junction protein, alpha 1, 43kDa
Gene Ontology
HyperlinkGene Summary
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia and heart malformations. [provided by RefSeq
Other Designations
OTTHUMP00000017111|connexin 43|gap junction 43 kDa heart protein|gap junction protein, alpha-like
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Interactome
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Pathway
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Disease
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Publication Reference
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A new GJA1 (connexin 43) mutation causing oculodentodigital dysplasia associated to uncommon features.
de la Parra DR, Zenteno JC.
Ophthalmic Genetics 2007 Dec; 28(4):198.
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A new GJA1 (connexin 43) mutation causing oculodentodigital dysplasia associated to uncommon features.
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