F2R polyclonal antibody
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Specification
Product Description
Goat polyclonal antibody raised against synthetic peptide of F2R.
Immunogen
A synthetic peptide corresponding to human F2R.
Sequence
C-TRARRPESKATNAT
Host
Goat
Theoretical MW (kDa)
47.4
Reactivity
Human
Specificity
Approx 48 KDa band observed in HeLa cell lysate (calculated MW of 47.4 KDa according to NP_001983.2).
Form
Liquid
Purification
Antigen affinity purification
Concentration
0.5 mg/mL
Recommend Usage
ELISA (1:32000)
Western Blot (0.5-2 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In Tris saline, pH 7.3 (0.5% BSA, 0.02% sodium azide)
Storage Instruction
Store at -20°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
F2R polyclonal antibody (Cat # PAB14138) (0.5 ug/mL) staining of HeLa lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.Enzyme-linked Immunoabsorbent Assay
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Gene Info — F2R
Entrez GeneID
2149Protein Accession#
NP_001983.2Gene Name
F2R
Gene Alias
CF2R, HTR, PAR1, TR
Gene Description
coagulation factor II (thrombin) receptor
Omim ID
187930Gene Ontology
HyperlinkGene Summary
Coagulation factor II receptor is a 7-transmembrane receptor involved in the regulation of thrombotic response. Proteolytic cleavage leads to the activation of the receptor. F2R is a G-protein coupled receptor family member. [provided by RefSeq
Other Designations
coagulation factor II receptor|protease-activated receptor 1|thrombin receptor
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Interactome
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Pathway
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Disease
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Publication Reference
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Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.
Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W.
Nature 2008 Apr; 452(7187):654.
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Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation.
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