CBX1 polyclonal antibody
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More Files
- More Functions
Western Blot (Cell lysate)
Western blot was performed on nuclear extracts from HeLa cells (HeLa NE, 20 ug) with CBX1 polyclonal antibody (Cat # PAB14123) diluted 1 : 1,000 in TBS-Tween containing 5% skimmed milk.
The expected location of CBX1, CBX3, and CBX5 is indicated on the right.
The HP1 antibody is not specific for CBX1, but also recognizes CBX3 and CBX5.
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Specification
Product Description
Rabbit polyclonal antibody raised against full length recombinant CBX1.
Immunogen
Recombinant GST fusion protein corresponding to full length human CBX1.
Host
Rabbit
Reactivity
Human
Specificity
This antibody also recognizes CBX5 and CBX3.
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide, 0.05% proclin 300)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot was performed on nuclear extracts from HeLa cells (HeLa NE, 20 ug) with CBX1 polyclonal antibody (Cat # PAB14123) diluted 1 : 1,000 in TBS-Tween containing 5% skimmed milk.
The expected location of CBX1, CBX3, and CBX5 is indicated on the right.
The HP1 antibody is not specific for CBX1, but also recognizes CBX3 and CBX5. -
Gene Info — CBX1
Entrez GeneID
10951Protein Accession#
P83916Gene Name
CBX1
Gene Alias
CBX, HP1-BETA, HP1Hs-beta, HP1Hsbeta, M31, MOD1, p25beta
Gene Description
chromobox homolog 1 (HP1 beta homolog Drosophila )
Omim ID
604511Gene Ontology
HyperlinkGene Summary
This gene encodes a highly conserved nonhistone protein, which is a member of the heterochromatin protein family . The protein is enriched in the heterochromatin and associated with centromeres. The protein has a single N-terminal chromodomain which can bind to histone proteins via methylated lysine residues, and a C-terminal chromo shadow-domain (CSD) which is responsible for the homodimerization and interaction with a number of chromatin-associated nonhistone proteins. The protein may play an important role in the epigenetic control of chromatin structure and gene expression. Several related pseudogenes are located on chromosomes 1, 3, and X. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq
Other Designations
heterochromatin protein 1-beta|heterochromatin protein p25 beta|modifier 1 protein
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