SSRP1 polyclonal antibody
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More Files
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Specifications
Product Description
Rabbit polyclonal antibody raised against partial recombinant SSRP1.
Immunogen
Recombinant GST fusion protein corresponding to N-terminus of human SSRP1.
Host
Rabbit
Reactivity
Human
Form
Liquid
Recommend Usage
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.05% sodium azide, 0.05% proclin 300)
Storage Instruction
Store at -20°C. For long term storage store at -80°C.
Aliquot to avoid repeated freezing and thawing.Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot was performed using nuclear extracts from HeLa cells (HeLa NE, 20 ug) and the SSRP1 polyclonal antibody (Cat # PAB14118) at dilution 1 : 1,000 in TBS-Tween + 5% skimmed milk. -
Gene Info — SSRP1
Entrez GeneID
6749Protein Accession#
Q08945Gene Name
SSRP1
Gene Alias
FACT, FACT80, T160
Gene Description
structure specific recognition protein 1
Omim ID
604328Gene Ontology
HyperlinkGene Summary
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq
Other Designations
chromatin-specific transcription elongation factor 80 kDa subunit|cisplatin-DNA SSRP|facilitates chromatin remodeling 80 kDa subunit|high mobility group box|recombination signal sequence recognition protein
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