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Last updated: 2017/8/13
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COL1A1/COL1A2 polyclonal antibody

  • Catalog # : PAB13922
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  • Specification
  • Product Description:
  • Goat polyclonal antibody raised against COL1A1/COL1A2.
  • Immunogen:
  • Human COL1A1/COL1A2.
  • Host:
  • Goat
  • Reactivity:
  • Human
  • Specificity:
  • Reacts with conformational determinants on human type I collagen as demonstrated by ELISA. May react with type I collagen from other species. Exhibits <10% cross reactivity with collagen types II, III, IV, V and VI. Has not been tested for reactivity with other extracellular matrix proteins (e.g. laminin, fibronectin).
  • Form:
  • Liquid
  • Recommend Usage:
  • Immunohistochemistry (Frozen sections) (1:10-1:20)
    Immunocytochemistry (1:10-1:20)
    The optimal working dilution should be determined by the end user.
  • Storage Buffer:
  • In 100 mM BBS, pH 8.2
  • Storage Instruction:
  • Store at 4°C.
  • Publication Reference
  • Applications
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • ELISA
  • Dot Blot
  • Enzyme Immunoassay
  • Application Image
  • Immunohistochemistry (Frozen sections)
  • Immunocytochemistry
  • ELISA
  • Dot Blot
  • Enzyme Immunoassay
  • Gene Information
  • Entrez GeneID:
  • 1277
  • Gene Name:
  • COL1A1
  • Gene Alias:
  • OI4
  • Gene Description:
  • collagen, type I, alpha 1
  • Gene Summary:
  • This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
  • Other Designations:
  • alpha 1 type I collagen,collagen alpha 1 chain type I,collagen of skin, tendon and bone, alpha-1 chain,pro-alpha-1 collagen type 1,type I collagen alpha 1 chain
  • Gene Information
  • Entrez GeneID:
  • 1278
  • Gene Name:
  • COL1A2
  • Gene Alias:
  • OI4
  • Gene Description:
  • collagen, type I, alpha 2
  • Gene Summary:
  • This gene encodes the pro-alpha2 chain of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIB, recessive Ehlers-Danlos syndrome Classical type, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for the alpha1 chain of type I collagen (COL1A1) reflecting the different role of alpha2 chains in matrix integrity. Three transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish
  • Other Designations:
  • alpha 2 type I collagen,alpha 2(I)-collagen,alpha-2 collagen type I,collagen I, alpha-2 polypeptide,collagen of skin, tendon and bone, alpha-2 chain,type I procollagen
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