Goat polyclonal antibody raised against 5-Hydroxymethyluridine.
5-Hydroxymethyluridine conjugated with BSA.
5-Hydroxymethyl-2-deoxyuridine and 5-Hydroxymethyluridine. Formed from thymidine during the oxidation of DNA by ionizing radiation or reactive oxygen species (ROS) that are formed from inflammatory response. This causes genetic mutations, altered gene expression and chromosomal instability that has generally been implicated with aging, cancers and autoimmune disease. Specificity was determined by competitive ELISA: Cross-reactivity: 5-Hydroxy-2-deoxyuridine (5-HmdUrd) 100% 5-Hydroxymethyluridine (5-HmUrd) 100% Thymidine (T) 60% Hydroxymethyluracil (HmU) 43% Deoxyuridine (dUrd) 36% Uridine (Urd) 32% Uracil (U) 0%
ELISA (>1:25000) The optimal working dilution should be determined by the end user.
In buffer containing 0.09% sodium azide
Store at 4°C. For long term storage store at -20°C. Aliquot to avoid repeated freezing and thawing.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.