PLAU polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against native PLAU.
Immunogen
Native purified human PLAU.
Host
Rabbit
Reactivity
Human
Specificity
human Urokinase.
Form
Liquid
Recommend Usage
ELISA (1:10000)
Western Blot (1:1000)
The optimal working dilution should be determined by the end user.Storage Buffer
In 50 mM sodium phosphate buffer, 100 mM NaCl, 1mM EDTA, pH 6.6
Storage Instruction
Store at -80°C.
Aliquot to avoid repeated freezing and thawing. -
Applications
Western Blot
Immunohistochemistry
Enzyme-linked Immunoabsorbent Assay
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Gene Info — PLAU
Entrez GeneID
5328Gene Name
PLAU
Gene Alias
ATF, UPA, URK, UROKINASE, u-PA
Gene Description
plasminogen activator, urokinase
Gene Ontology
HyperlinkGene Summary
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer's disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq
Other Designations
OTTHUMP00000019849|U-plasminogen activator|antagonist of uPA|plasminogen activator, urinary|urokinase plasminogen activator|urokinase-type plasminogen activator amino-terminal fragment
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