CASP8AP2 polyclonal antibody
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Specification
Product Description
Rabbit polyclonal antibody raised against synthetic peptide of CASP8AP2.
Immunogen
A synthetic peptide corresponding to C-terminus of human CASP8AP2.
Host
Rabbit
Reactivity
Human
Specificity
Recognizes FLASH.
Form
Liquid
Recommend Usage
Western Blot (0.25-0.5 ug/mL)
Immunocytochemistry (10 ug/mL)
The optimal working dilution should be determined by the end user.Storage Buffer
In PBS (0.02% sodium azide)
Storage Instruction
Store at 4°C.
Note
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Applications
Western Blot (Cell lysate)
Western blot analysis of CASP8AP2 in HeLa whole cell lysates with CASP8AP2 polyclonal antibody (Cat # PAB13803) at 0.5 ug/mL .Immunocytochemistry
Immunocytochemistry of CASP8AP2 in HeLa cells with CASP8AP2 polyclonal antibody (Cat # PAB13803) at 10 ug/mL . -
Gene Info — CASP8AP2
Entrez GeneID
9994GeneBank Accession#
Q9UKL3Gene Name
CASP8AP2
Gene Alias
CED-4, FLASH, FLJ11208, KIAA1315, RIP25
Gene Description
caspase 8 associated protein 2
Omim ID
606880Gene Ontology
HyperlinkGene Summary
This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein
Other Designations
CASP8 associated protein 2|FLASH homolog RIP25|FLICE associated huge|FLICE-associated huge protein|human FLASH
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Interactome
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Disease
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