Detection of endogenous CRADD (human) in HEK293T cells by CRADD polyclonal antibody (Cat # PAB13793) at 1 : 1000 dilution. Total cell extracts (50 ug) were run on a SDS-gel followed by incubation with HRP-coupled anti-rabbit secondary antibody.
The protein encoded by this gene is a death domain (CARD/DD)-containing protein and has been shown to induce cell apoptosis. Through its CARD domain, this protein interacts with, and thus recruits, caspase 2/ICH1 to the cell death signal transduction complex that includes tumor necrosis factor receptor 1 (TNFR1A), RIPK1/RIP kinase, and numbers of other CARD domain-containing proteins. [provided by RefSeq
RIP-associated ICH1/CED3-homologous protein with death domain,RIP-associated protein with a death domain,caspase and RIP adaptor with death domain,death adaptor molecule RAIDD,death domain containing protein CRADD